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Zolpidem 10mg In Stock

$60.00$160.00

This listing is for a single box (30 pills).
This product is supplied in the original blister packaging from the pharmacy.
This product ships from Europe.
The delivery time for this product to Europe is 7 – 14 days.

SKU: 5246416-16 Category:

Description

Introduction

Zolpidem, commonly marketed under the brand name Ambien, is a medication primarily used for the short-term treatment of insomnia. It belongs to a class of drugs known as sedative-hypnotics and is widely prescribed to help individuals with sleep initiation difficulties. In this comprehensive guide, we will explore the pharmacology, uses, side effects, precautions, and other important aspects of Zolpidem.

Pharmacology of Zolpidem

Zolpidem acts as a selective agonist at the gamma-aminobutyric acid (GABA) type A receptor, specifically targeting the alpha-1 subunit. By enhancing the inhibitory effects of GABA, it promotes sleep by reducing neuronal excitability and inducing sedation. This mechanism is distinct from benzodiazepines, although Zolpidem shares some similarities in its pharmacological effects.

Uses of Zolpidem

  1. Insomnia Treatment: Zolpidem is primarily prescribed for the short-term management of insomnia, especially for individuals who have difficulty falling asleep.
  2. Shift Work Sleep Disorder: It may be used off-label to treat shift work sleep disorder, helping individuals adjust their sleep patterns when working non-traditional hours.
  3. Anxiolytic Effects: In some cases, Zolpidem may exhibit anxiolytic (anxiety-reducing) properties, although it is not primarily indicated for this purpose.

Forms and Dosage

Zolpidem is available in several forms, including immediate-release tablets, extended-release tablets, and sublingual tablets. The dosage varies depending on the formulation and the individual’s specific needs. Typically, the initial recommended dose for adults is 5 to 10 mg taken orally at bedtime. The extended-release form may have different dosing guidelines and should be taken as directed by a healthcare professional.

Side Effects

  1. Common Side Effects: The most common side effects of Zolpidem include drowsiness, dizziness, headache, and gastrointestinal disturbances such as nausea or vomiting.
  2. Paradoxical Reactions: In some cases, Zolpidem can cause paradoxical reactions, leading to increased agitation, confusion, or aggressive behavior. These reactions are rare but can be concerning.
  3. Dependency and Withdrawal: Long-term use of Zolpidem can lead to dependency, and abrupt discontinuation may result in withdrawal symptoms such as rebound insomnia, anxiety, or tremors.

Precautions and Warnings

  1. Avoid Alcohol: It is important to avoid alcohol consumption while taking Zolpidem, as it can increase the risk of severe drowsiness and respiratory depression.
  2. Driving and Machinery: Due to its sedative effects, Zolpidem can impair cognitive and motor function. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
  3. Pregnancy and Lactation: Zolpidem should be used with caution during pregnancy and lactation, as its safety in these situations is not well established. Consultation with a healthcare provider is essential in such cases.

Overdose and Treatment

In cases of Zolpidem overdose, symptoms may include excessive sedation, respiratory depression, and coma. Treatment involves supportive measures such as maintaining airway patency, administering activated charcoal if appropriate, and monitoring vital signs. In severe cases, medical intervention in a hospital setting may be necessary.

Interactions with Other Medications

Zolpidem can interact with several other medications, including:

  • Central Nervous System Depressants: Concurrent use with other CNS depressants such as benzodiazepines or opioids can potentiate sedation and respiratory depression.
  • Cytochrome P450 Inhibitors: Drugs that inhibit CYP3A4 can increase Zolpidem levels in the blood, leading to enhanced effects and potential toxicity.
  • Alcohol: Combining Zolpidem with alcohol is contraindicated due to the increased risk of adverse effects.

Conclusion

Zolpidem, or Ambien, is a widely used medication for the short-term management of insomnia. Its pharmacological actions involve enhancing GABAergic transmission, leading to sedation and improved sleep initiation. While generally effective, it is essential to use Zolpidem cautiously, avoiding long-term use and potential interactions with other medications. Consulting with a healthcare provider for proper dosage and monitoring is crucial for safe and effective treatment.

Additional information

Pillen

30, 60, 90, 180

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